Cryptic crossword clue
Irritated, being married, to lose husband 6

The most common and most likely answer to this crossword clue is the 6 letter word ITCHED

I've seen this crossword clue in The Guardian
I
T
C
H
E
D

Buddy explains!

The straight part
We know that "Irritated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case irritated = itched.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ITCHED mean?

ITCHED verb
  1. To feel itchy; to feel a need to be scratched.
  2. To have a constant, teasing urge; to feel strongly motivated; to want or desire something.
  3. To cause to feel an itch.
  4. To scratch or rub so as to relieve an itch.

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