Cryptic crossword clue
Irritated chimpanzee drops hot pin resulting in skin problem  6

The most common and most likely answer to this crossword clue is the 6 letter word ECZEMA

E
C
Z
E
M
A


Buddy explains!

The straight part
We know that "skin problem" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case skin problem = eczema.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ECZEMA mean?

ECZEMA noun
  1. A non-contagious acute or chronic inflammation of the skin, characterized by redness, itching, and the outbreak of oozing vesicular lesions which become encrusted and scaly.

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