Cryptic crossword clue
Irritated high Tory expressing acquiescence 6-2

The most common and most likely answer to this crossword clue is the 6 letter word RIGHTY

R
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G
H
T
Y

Buddy explains!

The straight part
We know that "expressing acquiescence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case expressing acquiescence = righty.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RIGHTY mean?

RIGHTY noun
  1. A right-handed person.
  2. A right-wing person.
RIGHTY interjection
  1. Right; used to indicate agreement or change of topic.

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