Cryptic crossword clue
Irritation shown by gambler cleaned out in William Hill, say 7

The most common and most likely answer to this crossword clue is the 7 letter word CHAGRIN

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Irritation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case irritation = chagrin.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHAGRIN mean?

CHAGRIN noun
  1. Distress of mind caused by a failure of aims or plans, want of appreciation, mistakes etc; vexation or mortification.
  2. A type of leather or skin with a rough surface.
CHAGRIN verb
  1. To bother or vex; to mortify.
  2. To be vexed or annoyed.
CHAGRIN adjective
  1. Feeling chagrin; annoyed; vexed, fretful.

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