Cryptic crossword clue
Is taking large, large pains 4

The most common and most likely answer to this crossword clue is the 4 letter word ILLS

I
L
L
S


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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ILLS mean?

ILLS noun
  1. (often pluralized) Trouble; distress; misfortune; adversity.
  2. Harm or injury.
  3. Evil; moral wrongfulness.
  4. A physical ailment; an illness.
  5. PCP, phencyclidine.

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