Cryptic crossword clue
Isn’t prepared to have doctor probing Very personal 6

The most common and most likely answer to this crossword clue is the 6 letter word INMOST

I
N
M
O
S
T

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The straight part
We know that "Very personal" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very personal = inmost.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INMOST mean?

INMOST noun
  1. That which is innermost; the core.
INMOST adjective
  1. The very deepest within; farthest from the surface or external part; innermost

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