Cryptic crossword clue
Isolate soil pipe with search for its centre 9

The most common and most likely answer to this crossword clue is the 9 letter word SEQUESTER

I've seen this crossword clue in The Times
S
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Buddy explains!

The straight part
We know that "Isolate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case isolate = sequester.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEQUESTER mean?

SEQUESTER noun
  1. Sequestration; separation
  2. A person with whom two or more contending parties deposit the subject matter of the controversy; one who mediates between two parties; a referee.
  3. A sequestrum.
SEQUESTER verb
  1. To separate from all external influence; to seclude; to withdraw.
  2. To separate in order to store.
  3. To set apart; to put aside; to remove; to separate from other things.
  4. To prevent an ion in solution from behaving normally by forming a coordination compound
  5. To temporarily remove (property) from the possession of its owner and hold it as security against legal claims.
  6. To cause (one) to submit to the process of sequestration; to deprive (one) of one's estate, property, etc.
  7. To remove (certain funds) automatically from a budget.
  8. To seize and hold enemy property.
  9. To withdraw; to retire.
  10. To renounce (as a widow may) any concern with the estate of her husband.

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