Cryptic crossword clue
It applies make-up and isn’t mixed in store 8

The most common and most likely answer to this crossword clue is the 8 letter word PANSTICK

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Buddy explains!

The straight part
We know that "It applies make-up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it applies make-up = panstick.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PANSTICK mean?

PANSTICK noun
  1. A form of pancake makeup supplied in a tube, like lipstick.

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