Cryptic crossword clue
It could be risky when high escort tottering around chamber gets a little loud 11

The most common and most likely answer to this crossword clue is the 11 letter word CHOLESTEROL

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Buddy explains!

The straight part
We know that "It could be risky when high" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it could be risky when high = cholesterol.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHOLESTEROL mean?

CHOLESTEROL noun
  1. A sterol lipid synthesized by the liver and transported in the bloodstream to the membranes of all animal cells; it plays a central role in many biochemical processes and, as a lipoprotein that coats the walls of blood vessels, is associated with cardiovascular disease.
  2. The level of cholesterol in the body.

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