Cryptic crossword clue
It is Annie's misguided follies 10

The most common and most likely answer to this crossword clue is the 10 letter word INSANITIES

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does INSANITIES mean?

INSANITIES noun
  1. The state of being insane; madness.

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