Cryptic crossword clue
It makes us turn up as well

The most common and most likely answer to this crossword clue is the 3 letter word DNA

I've seen this crossword clue in The Guardian
D
N
A

Buddy explains!

The straight part
We know that "It makes us" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it makes us = dna.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DNA mean?

DNA noun
  1. The part of a living being that carries genetic information.
  2. A biopolymer of deoxyribonucleic acid (a type of nucleic acid) that has four different chemical groups, called bases: adenine, guanine, cytosine, and thymine.
  3. The fundamental values or vision of an organization.

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