Cryptic crossword clue
It makes you an ugly little man when injecting drug 6

The most common and most likely answer to this crossword clue is the 6 letter word GENOME

G
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N
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GENOME mean?

GENOME noun
  1. The complete genetic information (either DNA or, in some viruses, RNA) of an organism.

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