The most common and most likely answer to this crossword clue is the 8 letter word NIHILISM
I've seen this crossword clue in Financial Times
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More clues leading to the result NIHILISM
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does NIHILISM mean?
NIHILISM noun- (usually uncountable) The view that all endeavours are devoid of objective meaning.
- (usually uncountable) The rejection of, or opposition to, religious beliefs, (inherent or objective) moral principles, legal rules, etc., often due to the view that life is meaningless (sense 1).
- (usually uncountable) The rejection of non-proven or non-rationalized assertions in the social and political spheres of society.
- A delusion that oneself or the world, or parts thereof, have ceased to exist.
- (Russia) Alternative letter-case form of Nihilism
- A doctrine grounded on the negation of one or more meaningful aspects of life; in particular, the view that nothing in the world actually exists.
- Something that is regarded as meaningless.