Cryptic crossword clue
It perks up old wine, substance including last in vat 4

The most common and most likely answer to this crossword clue is the 4 letter word STUM

S
T
U
M

Buddy explains!

The straight part
We know that "It perks up old wine" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it perks up old wine = stum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STUM mean?

STUM noun
  1. Unfermented grape juice; must.
  2. Wine revived by new fermentation, resulting from the admixture of must.
STUM verb
  1. To ferment.
  2. To renew (wine etc.) by mixing must with it and raising a new fermentation.
  3. To fume, as a cask of liquor, with burning sulphur.

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