Cryptic crossword clue
It primarily leads to myocardial infarction, embodied by terrible aches 8

The most common and most likely answer to this crossword clue is the 8 letter word ISCHEMIA

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The cryptic/wordplay part
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What does ISCHEMIA mean?

ISCHEMIA noun
  1. Local disturbance in blood circulation due to mechanical obstruction of the blood supply (vasoconstriction, thrombosis or embolism).

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