Cryptic crossword clue
It shows drug’s “up” times 3

The most common and most likely answer to this crossword clue is the 3 letter word SEX

I've seen this crossword clue in The Guardian
S
E
X

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The straight part
We know that "It" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it = sex.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEX mean?

SEX noun
  1. A category into which sexually-reproducing organisms are divided on the basis of their reproductive roles in their species.
  2. Another category, especially of humans and especially based on sexuality or gender roles.
  3. The members of such a category, taken collectively.
  4. The distinction and relation between these categories, especially in humans; gender.
  5. (with "the") Women; the human female sex and those who belong to it.
  6. Sexual activity, usually sexual intercourse unless preceded by a modifier.
  7. Genitalia: a penis or vagina.
SEX verb
  1. To determine the sex of an animal.
  2. To have sex with.
SEX noun
  1. An offshoot of a larger religion; a group sharing particular (often unorthodox) political and/or religious beliefs.
  2. A group following a specific ideal or a leader.
  3. A cutting; a scion.

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