Cryptic crossword clue
Italian city not quite maintaining already disagreeable relationship with host 10

The most common and most likely answer to this crossword clue is the 10 letter word PARASITISM

I've seen this crossword clue in The Sunday Telegraph
P
A
R
A
S
I
T
I
S
M

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PARASITISM mean?

PARASITISM noun
  1. Interaction between two organisms, in which one organism (the parasite) benefits and the other (the host) is harmed.
  2. A similar interaction between people.

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