The most common and most likely answer to this crossword clue is the 6 letter word MAFIAS
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The straight part
We know that "Italian family gangs" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case italian family gangs = mafias.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MAFIAS mean?
MAFIAS noun- A hierarchically structured secret organisation engaged in illegal activities like distribution of narcotics, gambling and extortion.
- A crime syndicate.
- A trusted group of associates, as of a political leader.
- (in compound terms such as "moral mafia") An entity which attempts to control a specified arena.