Cryptic crossword clue
It’ll be the death of me training mum to get to grips with tango 10

The most common and most likely answer to this crossword clue is the 10 letter word PESTILENCE

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Buddy explains!

The straight part
We know that "It’ll be the death of me" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’ll be the death of me = pestilence.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PESTILENCE mean?

PESTILENCE noun
  1. Any epidemic disease that is highly contagious, infectious, virulent and devastating.
  2. Anything harmful to morals or public order.

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