The most common and most likely answer to this crossword clue is the 3 plus 5 plus 2 plus 5 letter word YOU CAN’T GO WRONG
I've seen this crossword clue in The Guardian
Y
O
U
C
A
N
â
€
™
T
G
O
W
R
O
N
G
Buddy explains!
The straight part
We know that "It’s a safe bet" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’s a safe bet = you can’t go wrong.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.