Cryptic crossword clue
It’s Goethe’s novel, so be very discriminating!

The most common and most likely answer to this crossword clue is the 9 letter word GHETTOISE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "be very discriminating" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case be very discriminating = ghettoise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GHETTOISE mean?

GHETTOISE verb
  1. To put (someone) in a ghetto, or to isolate as if in a ghetto.
  2. To make (a place) into a ghetto, or to add the characteristics of a ghetto.

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