Cryptic crossword clue
It’s taken away from rough brute’s hand 10

The most common and most likely answer to this crossword clue is the 10 letter word SUBTRAHEND

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "It’s taken away" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’s taken away = subtrahend.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SUBTRAHEND mean?

SUBTRAHEND noun
  1. A number or quantity to be subtracted from another.

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