The most common and most likely answer to this crossword clue is the 2 plus 6 letter word NO MATTER
I've seen this crossword clue in Financial Times
N
O
M
A
T
T
E
R
More clues leading to the result NO MATTER
- It's unimportant what would be left if the universe disappeared
- It’s unimportant, gossip old medium described
- Rattle on about honour? That’s insignificant!
- Gossip about old medium? It’s not important
- Regardless of what’s in a vacuum?
- Talk idly, accepting award? It’s not important
- Gas, including oxygen, beginning to materialise? It’s not important
- Mantra to crack social talk? It's unimportant
- Doing a volte-face on issue? Never mind
- Gossip involving old maiden? It’s not important
Buddy explains!

The straight part
We know that "It’s unimportant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’s unimportant = no matter.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.