The most common and most likely answer to this crossword clue is the 6 letter word UNTIES
U
N
T
I
E
S
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNTIES mean?
UNTIES verb- To loosen, as something interlaced or knotted; to disengage the parts of.
- To free from fastening or from restraint; to let loose; to unbind.
- To resolve; to unfold; to clear.
- To become untied or loosed.
- In the Perl programming language, to undo the process of tying, so that a variable uses default instead of custom functionality.