Cryptic crossword clue
Jacob’s son died, with collar showing one sign of dermatitis 8

The most common and most likely answer to this crossword clue is the 8 letter word DANDRUFF

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "sign of dermatitis/collar" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sign of dermatitis/collar = dandruff.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DANDRUFF mean?

DANDRUFF noun
  1. Scaly white dead skin flakes from the human scalp; Pityriasis capitis.
DANDRUFF verb
  1. To fall or cover with white flakes, like dandruff.

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