Cryptic crossword clue
Jane and I must fly nest 4

The most common and most likely answer to this crossword clue is the 4 letter word EYRE

E
Y
R
E


Buddy explains!

The straight part
We know that "Jane" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case jane = eyre.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EYRE mean?

EYRE noun
  1. A journey in circuit of certain itinerant judges called justices in eyre (or in itinere).

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