The most common and most likely answer to this crossword clue is the 9 letter word EMPHYSEMA
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More clues leading to the result EMPHYSEMA
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The cryptic/wordplay part
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What does EMPHYSEMA mean?
EMPHYSEMA noun- An abnormal accumulation of air or other gas in tissues, most commonly the lungs.
- Pulmonary emphysema, a chronic lung disease, one type of chronic obstructive pulmonary disease.