The most common and most likely answer to this crossword clue is the 10 letter word HYPOSTASIS
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More clues leading to the result HYPOSTASIS
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The cryptic/wordplay part
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What does HYPOSTASIS mean?
HYPOSTASIS noun- A sedimentary deposit, especially in urine.
- The essential person, specifically the single person of Christ (as distinguished from his two ‘natures’, human and divine), or of the three ‘persons’ of the Trinity (sharing a single ‘essence’).
- The underlying reality or substance of something.
- The effect of one gene preventing another from expressing.
- Postmortem lividity; livor mortis; suggillation.