The most common and most likely answer to this crossword clue is the 8 letter word CONFUSES
I've seen this crossword clue in The Daily Telegraph
C
O
N
F
U
S
E
S
More clues leading to the result CONFUSES
Buddy explains!

The straight part
We know that "puzzles" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case puzzles = confuses.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CONFUSES mean?
CONFUSES verb- To puzzle, perplex, baffle, bewilder (somebody).
- To mix up, muddle up (one thing with another); to mistake (one thing for another).
- To mix thoroughly; to confound; to disorder.
- To make uneasy and ashamed; to embarrass.
- To rout; discomfit.
- To be confused.