The most common and most likely answer to this crossword clue is the 7 letter word GALILEE
I've seen this crossword clue in Independent
G
A
L
I
L
E
E
More clues leading to the result GALILEE
- High wind besetting one lake gone finally – this one?
- Joy introducing the greatest Israeli region
- It’s an Israeli region I allege, wrongly
- Girl one brought to shelter in place of miracles
- Joy all over a Muslim town in the Middle East
- American boxer entering kind of club in Middle East region
- Biblical sea storm engulfing French island
- Girl and boy crossing top of Italian lake
Buddy explains!

The straight part
We know that "Israeli region" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case israeli region = galilee.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GALILEE mean?
GALILEE noun- A narthex, particularly in the United Kingdom and the Church of England; a vestibule, a fully-enclosed yet porch-like structure, leading to the main body of an English ecclesiastical building.
- In certain Syriac Christian churches, the baptistry.