The most common and most likely answer to this crossword clue is the 11 letter word JET-SETTERS
I've seen this crossword clue in The Guardian
J
E
T
-
S
E
T
T
E
R
S
More clues leading to the result JET-SETTERS
Buddy explains!
The straight part
We know that "They’re often 5" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they’re often 5 = jet-setters.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.