The most common and most likely answer to this crossword clue is the 6 plus 4 letter word NO-GO- AREA
I've seen this crossword clue in Financial Times
N
O
-
G
O
-
A
R
E
A
Buddy explains!
The straight part
We know that "Keep out of this" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case keep out of this = no-go- area.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.