Cryptic crossword clue
Key ancestors of humans primarily transformed mechanism used in timepieces 10

The most common and most likely answer to this crossword clue is the 10 letter word ESCAPEMENT

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Buddy explains!

The straight part
We know that "mechanism used in timepieces" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mechanism used in timepieces = escapement.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

ESCAPEMENT noun
  1. The contrivance in a timepiece (winding wristwatch) which connects the train of wheel work with the pendulum or balance, giving to the latter the impulse by which it is kept in vibration.
  2. A mechanism found in devices such as a typewriter or printer which controls lateral motion of the carriage.
  3. An escape or means of escape.
  4. The number of fish that escape commercial fishing operations and travel upstream to spawn.

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