Cryptic crossword clue
Key defender is one who can get out of a tight spot 12

The most common and most likely answer to this crossword clue is the 12 letter word ESCAPOLOGIST

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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Crossword Answer definitions

ESCAPOLOGIST noun
  1. An entertainer skilled in the art of escapology.

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