The most common and most likely answer to this crossword clue is the 5 letter word TONIC
I've seen this crossword clue in Financial Times
T
O
N
I
C
More clues leading to the result TONIC
- Restorative note
- Note a reviver?
- Turned in, occupying bed after knocking back medicine
- At home, confined to bed, rejected pick-me-up
- Do not put up with it casually at first!
- Do taking place with team leader in charge
- Shot in the arm and leg when captured by movement out of control?
- Medicine working to stop twitch
- Livener to take, short
- Opener for county going after century, one that's refreshing
Buddy explains!

The straight part
We know that "Keynote" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case keynote = tonic.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TONIC mean?
TONIC noun- A substance with medicinal properties intended to restore or invigorate.
- Tonic water.
- (Massachusetts) Any of various carbonated, non-alcoholic beverages; soda pop.
- Someone or something that revitalises or reinvigorates.
- Pertaining to tension, especially of muscles.
- Restorative, curative or invigorating.
- The first note of a diatonic scale; the keynote.
- The triad built on the tonic note.
- A tonic element or letter; a vowel or a diphthong.
- Pertaining to or based upon the first note of a diatonic scale.
- Pertaining to the accent or stress in a word or in speech.
- Of or relating to tones or sounds; specifically being or relating to a speech sound made with tone unmixed and undimmed by obstruction, i.e. a vowel or diphthong.