Cryptic crossword clue
Kill number two following an upset 5

The most common and most likely answer to this crossword clue is the 5 letter word NAPOO

I've seen this crossword clue in Financial Times
N
A
P
O
O

Buddy explains!

The straight part
We know that "Kill" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case kill = napoo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NAPOO mean?

NAPOO verb
  1. To finish; to put an end to; to kill.
NAPOO adjective
  1. Finished, dead, no more, gone; non-existent.
  2. Dead.
NAPOO interjection
  1. There is no more.

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