The most common and most likely answer to this crossword clue is the 6 letter word HOBBLE
H
O
B
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The straight part
We know that "lame" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lame = hobble.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HOBBLE mean?
HOBBLE noun- (chiefly in the plural) One of the short straps tied between the legs of unfenced horses, allowing them to wander short distances but preventing them from running off.
- An unsteady, off-balance step.
- A difficult situation; a scrape.
- An odd job; a piece of casual work.
- To fetter by tying the legs; to restrict (a horse) with hobbles.
- To walk lame, or unevenly.
- To move roughly or irregularly.
- To perplex; to embarrass.