The most common and most likely answer to this crossword clue is the 5 plus 7 letter word XENIA ONATOPP
I've seen this crossword clue in Independent
X
E
N
I
A
O
N
A
T
O
P
P
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.