Cryptic crossword clue
Knob crashed one pick-up! 4

The most common and most likely answer to this crossword clue is the 4 letter word NODE

I've seen this crossword clue in Financial Times
N
O
D
E


Buddy explains!

The straight part
We know that "Knob" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case knob = node.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NODE mean?

NODE noun
  1. A knot, knob, protuberance or swelling.
  2. The point where the orbit of a planet, as viewed from the Sun, intersects the ecliptic. The ascending and descending nodes refer respectively to the points where the planet moves from South to North and N to S; their respective symbols are ☊ and ☋.
  3. A leaf node.
  4. A computer or other device attached to a network.
  5. The point at which the lines of a funicular machine meet from different angular directions; — called also knot.
  6. The point at which a curve crosses itself, being a double point of the curve. See crunode and acnode.
  7. A similar point on a surface, where there is more than one tangent-plane.
  8. A vertex or a leaf in a graph of a network, or other element in a data structure.
  9. A hard concretion or incrustation which forms upon bones attacked with rheumatism, gout, or syphilis; sometimes also, a swelling in the neighborhood of a joint.
  10. A point along a standing wave where the wave has minimal amplitude.
  11. The knot, intrigue, or plot of a dramatic work.
  12. A hole in the gnomon of a sundial, through which passes the ray of light which marks the hour of the day, the parallels of the Sun's declination, his place in the ecliptic, etc.
  13. The word of interest in a KWIC, surrounded by left and right cotexts.

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