Cryptic crossword clue
Knock out the suspect on top of Eiffel Tower 8

The most common and most likely answer to this crossword clue is the 8 letter word ETHERISE

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Buddy explains!

The straight part
We know that "Knock out" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case knock out = etherise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

ETHERISE verb
  1. To convert into ether.
  2. To render insensible by means of ether, as by inhalation.

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