Cryptic crossword clue
Knock over pass, I’m not sure for the substitute 5

The most common and most likely answer to this crossword clue is the 5 letter word LOCUM

I've seen this crossword clue in The Guardian
L
O
C
U
M


Buddy explains!

The straight part
We know that "substitute" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case substitute = locum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LOCUM mean?

LOCUM noun
  1. Short for locum tenens.
LOCUM noun
  1. A share in a Genoese trading vessel.

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