Cryptic crossword clue
Knock up designer range: time to impress Penny 10

The most common and most likely answer to this crossword clue is the 10 letter word IMPREGNATE

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "Knock up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case knock up = impregnate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPREGNATE mean?

IMPREGNATE verb
  1. To cause to become pregnant.
  2. To fertilize.
  3. To saturate, or infuse.
  4. To fill pores or spaces with a substance.
  5. To become pregnant.

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