Cryptic crossword clue
Knockout stuff from loch or ground 10

The most common and most likely answer to this crossword clue is the 10 letter word CHLOROFORM

I've seen this crossword clue in The Guardian
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The straight part
We know that "Knockout stuff" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case knockout stuff = chloroform.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

CHLOROFORM noun
  1. A halogenated hydrocarbon, trichloromethane, CHCl3; it is a volatile, sweet-smelling liquid, used extensively as a solvent and formerly as an anesthetic.
CHLOROFORM verb
  1. To treat with chloroform, or to render unconscious with chloroform.

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