The most common and most likely answer to this crossword clue is the 10 letter word KENSINGTON
I've seen this crossword clue in The Guardian
K
E
N
S
I
N
G
T
O
N
More clues leading to the result KENSINGTON
- Twitter plugs county working for London Region
- Know Carol’s not back in London
- Know Carol’s not up in London
- Know someone without a partner spurning the French area of London
- Under mayor Livingstone, say, serenade North London district
- Sonnet king composed in part of London
- Mr Livingstone’s home? Good negative feedback from part of London
Buddy explains!

The straight part
We know that "in London" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in london = kensington.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.