Cryptic crossword clue
Knowledgeable people in general will be afraid of starting off 4-4

The most common and most likely answer to this crossword clue is the 9 letter word WELL-READ

W
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Buddy explains!

The straight part
We know that "Knowledgeable" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case knowledgeable = well-read.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WELL-READ mean?

WELL-READ adjective
  1. Well informed and knowledgeable through having read extensively.

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