The most common and most likely answer to this crossword clue is the 6 letter word APATHY
I've seen this crossword clue in The Times
A
P
A
T
H
Y
More clues leading to the result APATHY
- Indifference in a way unknown
- Lack of enthusiasm for one heading off around track
- Route through a yard? There’s no interest in it
- Lack of interest, in a way, on the fourth of July
- A course of action ending in surly indifference
- A way granny finally shows lack of interest
- Not caring, needing some soap at hygienist’s
- Indifference always blocks the way
- Flatness of a route’s variable
- Indifference, in a way, over play’s ending
Buddy explains!

The straight part
We know that "Lack of enthusiasm" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lack of enthusiasm = apathy.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does APATHY mean?
APATHY noun- Lack of emotion or motivation; lack of interest or enthusiasm towards something; disinterest (in something).