Cryptic crossword clue
Lack of importance within certain sign, if I cancel 14

The most common and most likely answer to this crossword clue is the 14 letter word INSIGNIFICANCE

I've seen this crossword clue in The Sunday Telegraph
I
N
S
I
G
N
I
F
I
C
A
N
C
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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Crossword Answer definitions

INSIGNIFICANCE noun
  1. The state of being insignificant

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