The most common and most likely answer to this crossword clue is the 5 letter word DRIES
I've seen this crossword clue in Financial Times
D
R
I
E
S
More clues leading to the result DRIES
Buddy explains!

The straight part
We know that "loses moisture" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loses moisture = dries.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DRIES mean?
DRIES noun- The process by which something is dried.
- A prohibitionist (of alcoholic beverages).
- (with "the") The dry season.
- An area of waterless country.
- (UK politics) A radical or hard-line Conservative; especially, one who supported the policies of British Prime Minister Margaret Thatcher in the 1980s.
- To lose moisture.
- To remove moisture from.
- To be thirsty.
- To exhaust; to cause to run dry.
- For an actor to forget his or her lines while performing.