The most common and most likely answer to this crossword clue is the 10 letter word COUNTESSES
I've seen this crossword clue in The Daily Telegraph
C
O
U
N
T
E
S
S
E
S
More clues leading to the result COUNTESSES
Buddy explains!

The straight part
We know that "Ladies" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ladies = countesses.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does COUNTESSES mean?
COUNTESSES noun- The wife of a count or earl.
- A woman holding the rank of count or earl in her own right; a female holder of an earldom.