The most common and most likely answer to this crossword clue is the 6 letter word TOILET
I've seen this crossword clue in The Guardian
T
O
I
L
E
T
More clues leading to the result TOILET
- Going practice?
- Grooming hard worker to take time for run
- John the estate agent’s sign impresses paper
- Where one goes to, one allowed
- Work to tile WC
- Work hard for alien’s convenience
- Office available to tenants I installed
- Work on film that’s panned?
- Worked endlessly needing time for facilities
- One is found inside vacant lavatory
Buddy explains!

The straight part
We know that "Ladi/es/ possibly/i/n" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ladi/es/ possibly/i/n = toilet.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TOILET mean?
TOILET noun- A covering of linen, silk, or tapestry, spread over a dressing table in a chamber or dressing room.
- The table covered by such a cloth; a dressing table.
- Personal grooming; the process of washing, dressing and arranging the hair.
- One's style of dressing: dress, outfit.
- A dressing room.
- A room or enclosed area containing a toilet: a bathroom or water closet.
- A small secondary lavatory having a toilet and sink but no bathtub or shower.
- A chamber pot.
- A fixture used for urination and defecation, particularly those with a large bowl and ring-shaped seat which use water to flush the waste material into a septic tank or sewer system.
- A very shabby or dirty place.
- To dress and groom oneself
- To use the toilet
- To assist another (a child etc.) in using the toilet